Management of nicotinamide N-methyltransferase overexpression: inhibit the enzyme or reduce nicotinamide intake? Reply to Zhou S, Li D, Zhou Y [letter]
نویسندگان
چکیده
منابع مشابه
NNMT (nicotinamide N-methyltransferase)
The human NNMT gene is approximately 16,5 kb in length, consists of 3 exons and 2 introns, and is mapped to chromosome 11q23.1. The first intron is 1,240 bp in length, while the second is approximately 14 kb long. The sequence of the 5'-untranslated region (UTR) of the NNMT cDNA is present in exon 1, while the sequence of the cDNA 3'-UTR is present in exon 3 (Aksoy et al., 1995). The initiation...
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Letter by Zhou and Zhou Regarding Article, “Hypertension: Renin–Angiotensin– Aldosterone System Alterations” To the Editor: Activation of the renin–angiotensin–aldosterone system (RAAS) is believed to play an important role in hypertension. However, although having a higher risk of hypertension, blacks exhibit lower plasma renin levels compared with whites. Moreover, black hypertensives show an...
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Letter by Zhou and Zhou Regarding Article, “Hypertension: Renin–Angiotensin– Aldosterone System Alterations” To the Editor: Activation of the renin–angiotensin–aldosterone system (RAAS) is believed to play an important role in hypertension. However, although having a higher risk of hypertension, blacks exhibit lower plasma renin levels compared with whites. Moreover, black hypertensives show an...
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Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide. NNMT is strongly expressed in tumor cells and an increase in NNMT activity may reduce cellular nicotinamide level and thereby promote cell survival in the cells. However, there has been no report of a relationship between NNMT activity and nicotinamide level in tumor cells. We report herein that human glioma ce...
متن کاملZhonghe Zhou
Photo: Liwang Jin, Xinhua News Agency. Zhonghe Zhou began his career at Nanjing University in 1982, studying paleontology and stratigraphy. He received a Master of Science from the Graduate School of the Chinese Academy of Sciences (CAS), after which he went on to work at the Institute of Vertebrate Paleontology and Paleoanthropology (IVPP) CAS in Beijing, before attending graduate school at th...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2015
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-015-3678-5